Doing them consists of two parts. One is getting them cut (which I did myself in spring, but can't do now). The pre-work (configuring the CAD/CNC stuff) took about 1 hour. Assembling and cutting few moments. Adding structure is different. I made some very detailed with small round hammers (pic below), also I experimented a lot. I made ~12 runes in spring and that took one whole day. It's not too much work. What takes a lot of time is to get them rusted, but as they do that all by themselves (2-3 weeks) that is the laziest part. Finally I cleaned them and added varnish, that was about half an hour for three runes.
The most detailed one (mine,heh! which got a dive in saltwater to rust now since I loved the rusted!):
http://www.quaddicted.com/contribute/imageupload/images/spirit_quakerunes_2.jpg
The end1 rune took roughly 2 hours.