I want to find one of the breaker combos in a daily.

A few people have done them already - they're the guys who have a #1 position which eclipses everyone else by several magnitudes.

First that comes to mind is blank card + jera, which basically gives infinite items as soon as you find a battery. 

It's always bothered me that there is an item penalty. For me the whole goal of the game is to get as many items as you can.

Maybe its there to stop D100 runs or something. 

The massive top scores on the ingame leaderboard are all straight up cheaters actually.The game does basically nothing for sanity checking possible score per second, and barely anything to confirm the game isn't modded when a score is submitted.

GreedButt does do some sanity checking, but doesn't clarify how so hopefully cheaters won't get wise to break it... but you are right though that some of the high scores there are breaking runs that generate tons of coins and bombs and keys, but beyond those caps the time tends to cost more than the small extra points gained, so it tends that 50-60k is the maximum possible anyone can legitimately get in a run, but even that you must beat Boss Rush, Hush, and the Chest/Dark Room.

The idea behind the item penalty would've been sound if the game was better balanced... it's intended to reward you for skipping items, but it just ends up being meaningless becuase the penalty is so low, and even the shittiest items tend to be worth the minor hit. It's basically pointless. 

Today's Daily got super OP...

Tammy's Head + Brimstone + Car Battery + Guppy + Hive Mind.

Got 47,440 which is still only 350 so-ish ranking 

The story concludes: https://www.youtube.com/watch?v=EvAuU5y_WEU